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This lipid modification is essential because it affects: Drug half-life Albumin binding Pharmacokinetic behavior Without this modification, the therapeutic performance of semaglutide would change significantly

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Perhaps the most famous example is aspirin, which spent most of a century as a painkiller before a doctor in California named Lawrence Craven noticed that the patients he'd given aspirin gum to after tonsillectomies bled more than they should

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