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Within the GLP-1 analog, Ala8 is replaced by Gly to resist DPP-4 degradation, and Gly36 is substituted for Arg to avoid a potential T-cell epitope interaction [86]
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The trial is ongoing and will extend to 240 weeks to determine whether the histologic improvements observed at 72 weeks translate into reductions in mortality, liver transplant, and other major liver-related events
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