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The phosphorylated JAKs, especially JAK2, in turn stimulates the phosphorylation of three residues on the intracellular domain of LepRb (Tyr985, Tyr1077 and Tyr1138), and recruits distinct downstream signaling molecules to a leptin-specific signaling pathway to exhibit diverse physiological functions [84, 86]
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In a head-to-head study (SURPASS-2), Mounjaro topped Ozempic (1 mg semaglutide), showing it was more effective in helping patients keep their blood sugar levels in check and lose weight
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