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Preclinical data show that GLP-1—and by extension GLP-1R agonists—can modulate macrophage polarization: in vitro treatment of macrophages with GLP-1 reduced M1-specific markers (e.g., Inducible Nitric Oxide Synthase (iNOS), TNF-α, IL-6) and increased M2-associated markers (e.g., IL-10, CD163, CD204) via signaling pathways involving increased signal transducer and activator of transcription 3 (STAT3) activation, thereby promoting an anti-inflammatory M2 phenotype [51]
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Strength:10mg/2ml
10.1016/S0140-6736(20)30752-2
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