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GENETIC BACKGROUND Commonly encountered HTG is usually multigenic and results from small-effect variants (single nucleotide polymorphisms) in many genes or heterozygotes in genes such as APOA5, GCKR, LPL, and APOB that have larger effects and together, more than 20% of susceptibility is accounted for by common and rare variants (42)

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But it doesn’t follow that the majority of plans will necessarily jump to pay for the product, given the high cost and limited cost-effectiveness