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The table shows that resmetirom is a small (molecular weight about 600 g/mol), non-iodinated THR-β agonist administered once daily as an oral tablet, while semaglutide is a large (about 4 kDa) GLP-1 peptide designed for once-weekly subcutaneous injection or, with SNAC enhancement, once-daily oral administration
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Very lean individuals may need to pinch the skin to create a fold of subcutaneous fat before inserting the needle
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