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Los efectos sobre la evolución del FGe durante el seguimiento son variables entre los diferentes ensayos, con mínimas diferencias entre el grupo activo y placebo57,63,64, aunque un análisis exploratorio del estudio EXSCEL demostró una menor caída del FGe en pacientes con albuminurias superiores a 100mg/g y 200mg/g de creatinina95
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