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Additionally, some companies are researching ways to reduce further adverse effects, such as developing co-formulated anti-nausea compounds to improve tolerability .” Future research for GLP-1 therapies presents numerous possibilities
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In a combined analysis of subcutaneous (SUSTAIN-6) and oral [PIONEER 6 (NCT02692716)] T2DM CVOTs, semaglutide consistently reduced MACE risk versus placebo across all eGFR and urinary albumin:creatinine ratio (UACR) subgroups [58] Additionally, semaglutide (SELECT) reduced MACE in participants with overweight/obesity and baseline CVD but no T2DM [48]
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