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Additionally, GLP-1RAs were found to regulate food intake through stimulation of sensory neurons in the vagus, interaction with the hypothalamus and hindbrain, and through inflammation and intestinal microbiota

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PTRS Spotlight: The Best-Positioned Bet Isn’t Oral When we apply Intelligencia’s PTRS (Probability of Technical and Regulatory Success) framework, the most promising GLP-1–adjacent asset that is not already approved is CagriSema—a fixed-dose combination of cagrilintide (amylin analogue) and semaglutide, delivered as a once-weekly subcutaneous injection