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Survodutide, a single peptide targeting both the glucagon receptor (GCGR) and the GLP-1R also improved MASH with no worsening of fibrosis in 293 participants with a mean BMI of ∼36 by up to 62% vs
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The same research group also found that GLP-1 RA therapy significantly increased TT, fT, SHBG, and gonadotropin levels, with concurrent improvements in erectile function
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