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These compounds reduce central neuroinflammation by lowering interleukin (IL)-1β, IL-6, and tumor necrosis factor-alpha (TNF-α), and limiting oxidative stress ( On the other side, current trends in precision psychiatry aim to classify subpopulations of patients with inflammatory depression, characterized by elevated markers of inflammation, increased glucose and lipid levels, neurovegetative symptoms, anxiety or irritability, and suicidal ideation (Miller, 2025)

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