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The trials differed significantly in their design, including baseline patient characteristics (e.g., the REWIND trial included a majority of patients for primary prevention, whereas others focused on high-risk secondary prevention populations), follow-up duration, and specific drug properties, all of which likely contribute to the variable magnitude of benefit observed [63]

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rather, they offer valuable insight into the real-world impact of treatment and can help refine hypotheses about the pathophysiology of migraine