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In a range of AD animal models, treatment with GLP-1, GIP, or dual-GLP-1/GIP receptor agonists effectively protected cognition, synaptic trans-mission, long-term potentiation (LTP), and prevented the loss of synapses and neurons
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Therefore, DPP-IV inhibitors raise levels of endogenous GLP-1(7–36)amide, and it could be that at clinically relevant doses, this action of DPP-IV inhibitors produces a relatively selective increase of GLP-1(7–36)amide in the hepato-portal circulation or at the interface of L cells and vagal sensory nerve terminals
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