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ECD created a hydrophobic patch to engage the peptide C terminus mainly via residues in positions 22, 26, and 27, making extensive contacts with residues in the N-terminal α-helix, including V30 ECD , L32 ECD , V36 ECD , and W39 ECD , as well as one hydrogen bond with the backbone nitrogen of L32 ECD via 15 P (Asp in MEDI0382 and peptide 15, Glu in SAR425899 and GLP-1)

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Small particle size of a solid meal increases gastric emptying and late postprandial glycaemic response in diabetic subjects with gastroparesis