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The biological mechanism suggests it could occur, but the degree of appetite change and its long-term metabolic impact have not been defined in controlled clinical trials

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Although one study showed that tirzepatide did not affect the risk of diabetic retinopathy in patients with type 2 diabetes mellitus, however, there is still a need for large-scale randomized controlled trials are needed to assess the long-term safety of tirzepatide with respect to the risk of diabetic retinopathy ( A Korean study on antidiabetic drugs revealed significant sex differences, with females reporting more ADEs than males ( Our study analyzed the temporal relationship between drug administration and ADE onset time