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Interestingly, the SURPASS-2 trial found that patients on tirzepatide 5 mg experienced less nausea (17.4%) and vomiting (5.7%) compared to those on semaglutide 1 mg, who reported 19.2% nausea and 8.1% vomiting, despite tirzepatide leading to greater weight loss
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The interest in using Metformin for weight loss stems from personal experiences and limited clinical studies suggesting that it may help reduce appetite and improve insulin sensitivity, both of which could contribute to weight loss in some individuals
