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Crystal Structure of the Ligand-bound Glucagon-like Peptide-1 Receptor Extracellular Domain* - Journal of Biological Chemistry
Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have gained considerable attention in recent years as promising therapeutic agents for MASLD, particularly owing to their well-established efficacy in treating type 2 diabetes mellitus (T2DM) and obesity, conditions closely implicated to MASLD pathogenesis (2, 5)
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Furthermore, dual incretin agonists like tirzepatide exhibit superior efficacy, not only in reducing adipocyte size and visceral fat volume, but also in promoting BAT thermogenesis
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