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[9] [10] It works through multiple mechanisms: stimulating insulin secretion when blood glucose levels rise, suppressing glucagon release, slowing gastric emptying, and reducing appetite through effects on the brain
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Inclusion criteria were highly consistent across trials: Adults ≥18 years BMI ≥30 kg/m² (obese), or ≥27 kg/m² (overweight) with at least one weight-related comorbidity (e.g., hypertension, dyslipidemia, obstructive sleep apnea, or cardiovascular disease) Exclusion of patients with diagnosed type 1 or type 2 diabetes Documented history of unsuccessful dietary weight loss OASIS-1 Trial Designed to evaluate ultra-high-dose oral semaglutide (50 mg)
