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Tirzepatide is contraindicated in patients with personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2 due to rodent-based carcinogenicity signals in preclinical studies
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These established a safety profile indistinguishable from placebo — no effect on IGF-1, no impairment of glucose tolerance, no anti-AOD-9604 antibodies — but did NOT demonstrate clinically meaningful weight loss
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