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Medical supervision remains essential to ensure appropriate dosing, monitor for gastrointestinal tolerance, and screen for contraindications like personal or family history of medullary thyroid cancer

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What This Means Practically For patients with Type 2 diabetes, these findings have practical implications: First-line treatment recommendation: Major diabetes guidelines now recommend GLP-1 agonists as first-line treatment (alongside or instead of metformin) for patients with established cardiovascular disease