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This difference was observed in patients on different background therapies as placebo-controlled studies (PIONEER 1, 5, and 8) were conducted in patients receiving semaglutide in addition to diet and exercise, patients with moderate renal impairment using metformin, SU with or without metformin, or basal insulin with or without metformin, and in patients on stable treatment with insulin therapies with or without metformin
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