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Preclinical studies in accelerated mouse models of diet-induced steatohepatitis have demonstrated that retatrutide improves steatohepatitis through mechanisms involving enhanced hepatic fat oxidation, reduced lipogenesis, decreased inflammation, and attenuation of fibrosis markers, supporting the rationale for clinical development in MASH [33]
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In addition to managing type 2 diabetes and controlling weight, studies also found that these drugs may lower the risk of heart attacks and strokes, reduce alcohol consumption and improve brain and mental health
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