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The GRADE trial, which was designed to examine the comparative effectiveness of insulin glargine U-100, glimepiride, liraglutide, and sitagliptin in individuals with relatively short duration of diabetes (and without established CVD) with respect to achieving and maintaining A1C below 7%, found that individuals treated with liraglutide had a lower risk of cardiovascular events than individuals receiving the other three treatments (hazard ratio 0.7 [95% CI 0.6–0.9]), although no significant differences were found between individual treatment groups for major adverse cardiovascular events, hospitalization for HF, or cardiovascular death (137)
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