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Clinical trials show that oral semaglutide can be effective, though injectable semaglutide generally produces greater weight loss and stronger glucose lowering effects at comparable doses

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Local injection site reactions are the most common and typically include: Erythema (redness) and warmth at the injection site Swelling or induration (hardening of tissue) Pruritus (itching) or discomfort Bruising or nodule formation in some cases (particularly with exenatide extended-release formulations, where nodules are common and often non-allergic) These reactions usually appear within hours of injection and may resolve spontaneously within a few days