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Such molecular changes help to delineate putative mechanisms of action of the di-agonist, with consistent upregulation of factors involved in autophagy, neurotransmitter release, cytoskeletal remodeling, vesicle-mediated transport, and intracellular signaling, and downregulation of pathways related, among others, with oxidative stress, DNA repair and immune system in PWA mice, which showed consistent metabolic improvement at all doses of GLP1/E

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