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Doses typically escalate gradually over weeks or months to help minimize any side effects
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This is the same physiologic process seen when someone stops lifting weights: muscle size decreases because the stimulus is gone—not because muscle is being “destroyed.”² Common Misconception: “GLP-1 Drugs Burn Muscle” Reality: Muscle loss during GLP-1–associated weight loss is driven by reduced mechanical load and insufficient protein/calories , not by a toxic or catabolic drug effect.² ⁴ ⁹ When Lean-Mass Loss Becomes True Muscle Wasting True muscle wasting is uncommon with GLP-1 therapy and is usually related to undernutrition , not the medication itself
