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It should be pinpointed that while GIP acts almost exclusively at the pancreatic β level, there are widely distributed receptors for GLP-1 (R-GLP1) in the endocrine pancreas (α and β), in heart, stomach, adipose tissue, vagus nerve and in various regions of the central nervous system
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However, there was no such protective effect at lower dose of metformin (0.1 mmol/L) or liraglutide (3 and 10 nmol/L) (Fig
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