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Retatrutide is a triple hormone receptor agonist, acting on three receptors simultaneously: GLP-1 (glucagon-like peptide-1) — reduces appetite and slows gastric emptying GIP (glucose-dependent insulinotropic polypeptide) — enhances insulin secretion and may improve fat metabolism Glucagon receptor — increases energy expenditure and promotes fat breakdown It is worth noting that glucagon receptor agonism can, in isolation, raise blood glucose levels

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Skipping dose escalation steps or starting at higher doses increases the burden on your digestive system