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Common soluble fiber supplements include: Psyllium husk (Metamucil®, Konsyl®): derived from Plantago ovata seeds, contains approximately 70% soluble fiber Methylcellulose (Citrucel®): a semi-synthetic fiber that is non-fermentable and typically well-tolerated Inulin and oligofructose : prebiotic fibers that support beneficial gut bacteria but may increase gas production Wheat dextrin (Benefiber® Original): a soluble, low-viscosity fiber that dissolves completely in liquids Soluble fiber is particularly beneficial for patients with diarrhea-predominant symptoms, as it absorbs excess water and adds form to loose stools
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The SUSTAIN 6 trial demonstrated cardiovascular event reduction in diabetic patients on semaglutide, suggesting protective effects beyond weight loss alone
