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Common Side Effects (and When They Show Up) If you’ve just started semaglutide, you might notice some of the following symptoms during your first few doses: Nausea Diarrhea Constipation Fatigue Headache Indigestion or heartburn Bloating, gas, or burping (sometimes with a strong, sulfur-like smell) Dizziness Feeling full quickly or loss of appetite These are all pretty typical and tend to show up within the first 4 to 8 weeks, especially when you’re adjusting to the medication or increasing your dose
