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It mainly mediates the inhibitory effect of PYY (1-36) on insulin secretion and the vasoconstrictive effect ( Figure 1 Y2 receptors are primarily expressed in the CNS, including the arcuate nucleus of the hypothalamus, the solitary tract nucleus, and posterior regions of the brainstem, enteric neurons, and peripheral nerve endings ( Y4 receptors are widely distributed in peripheral tissues, particularly showing significant expression in the human small intestine, ileum, coronary arteries, and cardiac tissue ( + , jointly regulating intestinal smooth muscle tone and secretion, affecting gastric emptying and colonic motility ( Y5 receptors are primarily distributed in the CNS, with particularly high levels detected in the arcuate nucleus and paraventricular nucleus (PVN) of the hypothalamus ( + , and beta-inhibitor-mediated receptorization, which leads to complex tissue-specific cell responses

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