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Following our previously reported protocols with the NanoBiT tethering strategy 11 , the structures of retatrutide–GLP-1R–G s , retatrutide–GIPR–G s and retatrutide–GCGR–G s were determined using the single-particle cryo-EM with overall resolutions of 2.68 Å, 3.26 Å and 2.84 Å, respectively (Fig
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As a proxy, we evaluated the presence of MASH or cirrhosis, and the findings were consistent with the primary analysis
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