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Figure 1 Figure 2 Latest Researches on the Molecular Mechanisms and Pathogenies of Diabetes Mellitus In type 1 Diabetes, the pancreatic β-cells undergo autoimmune destruction by CD4+ and CD8+ T cells and macrophages which result in insulin deficiency ( The metabolic disorders related to type 1 diabetes mellitus are a result of deficiency of insulin secretion caused by the immune destruction of islets of Langerhans of the pancreas