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Others who plateau on semaglutide may benefit from switching between the two or even alternating protocols
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A recent study found that the ability of metformin to promote GLP-1 secretion was impaired in mice with a gut-specific knockout of the PEN2 gene ( (5) Metformin may also enhance GLP-1 secretion via the M3 cholinergic receptor and the gastrin-releasing peptide (GRP) receptor
