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Pharmacological activation of AMPK by administration of 5-aminoimidazole-4-carboxamide-1-β-d–ribofuranoside (AICAR) in either the 3rd [714] or the 4th ventricle [706] attenuates the anorectic effect of exendin-4 injected into the same ventricles

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Laut einer Metaanalyse randomisierter kontrollierter Studien können bis zu 40 % des Gewichtsverlusts unter Semaglutid aus Magermasse (Muskeln und Organe) stammen (Sargeant et al., Diabetes, Obesity and Metabolism 2024)